Statistical Genomics in Biomedical Research (10w5076)


(University of British Columbia)

Sandrine Dudoit (University of California, Berkeley)

Jane Fridlyand (Genentech Inc.)

(Ecole Polytechnique Federale de Lausanne)

Sunduz Keles (University of Wisconsin, Madison)

(Gladstone Institutes, University of California, San Francisco)


The Banff International Research Station will host the "Statistical Genomics in Biomedical Research" workshop from July 18 to 23, 2010.

The workshop is intended to foster deeper connections between basic and clinical scientists and statisticians and to be a forum for
(1) the dissemination of cutting-edge biotechnological and methodological developments;
(2) discussion of approaches to effective translation of putative biomarkers into clinical trial design;
and (3) the identification of open data analysis problems.
The challenges include analyzing genotypes, gene and protein expression and DNA-protein interaction data, relating these to phenotypic data, such as clinical outcomes and predicted mechanism of action of a drug, relating all of these to existing databases containing different types of meta-data, and finally incorporating the findings with clinical drug development. Mathematical problems in the field are diverse and touch upon statistical modeling, probability, computational and algorithmic optimization, and data visualization.

We anticipate that this workshop will enable statisticians to articulate grounded statistical formulations of existing and
emerging computational biological and clinical problems; create an exceptional opportunity for exchanging ideas; and provide a meaningful quantitative framework for translational research, bridging the gap between basic experimental findings and clinical practice. Necessarily interdisciplinary, meaningful advances can only take place with input from a variety of research backgrounds.

The Banff International Research Station for Mathematical Innovation and Discovery (BIRS) is a collaborative Canada-US-Mexico venture that provides an environment for creative interaction as well as the exchange of ideas, knowledge, and methods within the Mathematical Sciences, with related disciplines and with industry. The research station is located at The Banff Centre in Alberta and is supported by Canada's Natural Science and Engineering Research Council (NSERC), the US National Science Foundation (NSF), Alberta's Advanced Education and Technology, and Mexico's Consejo Nacional de Ciencia y Tecnologia (CONACYT).