Advances and Challenges in Protein-RNA: Recognition, Regulation and Prediction (15w5063)


(Technion-Israel Institute of Technology)

Gabriele Varani (University of Washington)


The Banff International Research Station will host the "Advances and Challenges in Protein-RNA: Recognition, Regulation and Prediction" workshop from June 7th to June 12th, 2015.

The function of all living organisms depends on the timely and precise regulation of the expression
of the genomic information during its development. Disregulation of these processes is observed in many
cancers and neurodegenerative diseases. In highly evolved organisms, such as humans, much regulation
occurs after the genome is copied into RNA intermediates during transcription. Many genes that code for
RNA without being translated into protein are involved in these processes, together with the proteins that
associate with them, yet most of these regulatory factors have only been discovered in the last ten years
or less, after the sequencing of the human genome. Understanding the molecular mechanisms that underline
these forms of regulation of genome expression is critical to understanding fundamental biology and
disease progression, and might lead to the discovery of new approaches to interfere with disease

The workshop will bring together experts experimental and computational biologists to share developments
in new methods that study these processes at the whole genome level. It will foster new collaborations
between experimental and computational biologists and catalyze the development of new and improved
technologies and ideas to merge experimental analysis with mathematical and computational techniques to
address this major challenge of biology and molecular medicine.

The Banff International Research Station for Mathematical Innovation and Discovery (BIRS) is a collaborative Canada-US-Mexico venture that provides an environment for creative interaction as well as the exchange of ideas, knowledge, and methods within the Mathematical Sciences, with related disciplines and with industry. The research station is located at The Banff Centre in Alberta and is supported by Canada's Natural Science and Engineering Research Council (NSERC), the U.S. National Science Foundation (NSF), Alberta's Advanced Education and Technology, and Mexico's Consejo Nacional de Ciencia y Tecnología (CONACYT).