Rules of Protein-DNA Recognition: Computational and Experimental Advances (15w5167)


(Columbia University)

(University of Southern California)


The Casa Matemática Oaxaca (CMO) will host the "Rules of Protein-DNA Recognition: Computational and Experimental Advances" workshop from June 21st to June 26th, 2015.

The information that determines our genetic make-up – from our eye color to our propensity to get cancer or Alzheimer’s disease – is encoded in the DNA sequence of our genomes. This information is interpreted by specialized proteins called transcription factors that ‘read’ the four-letter code in our DNA. Although the set of transcription factors present in living cells are fully proficient at reading and interpreting this code, humans currently are unable to decipher the non-protein-coding portion of our genomes, which comprises >95% of our DNA. Now that we have literally thousands of fully sequenced genomes, one of the major challenges facing computational and structural biologists is to crack this code. The solution to this challenge will likely come from the convergence of theoretical, computational, biophysical, and structural approaches. The BIRS format is ideal for bringing together this combination of scientists in an informal and collaborative setting to further advance this goal.

The Casa Matemática Oaxaca (CMO) in Mexico, and the Banff International Research Station for Mathematical Innovation and Discovery (BIRS) in Banff, are collaborative Canada-US-Mexico ventures that provide an environment for creative interaction as well as the exchange of ideas, knowledge, and methods within the Mathematical Sciences, with related disciplines and with industry.

The research station in Banff is supported by Canada's Natural Science and Engineering Research Council (NSERC), the U.S. National Science Foundation (NSF), Alberta's Advanced Education and Technology, and Mexico's Consejo Nacional de Ciencia y Tecnología (CONACYT). The research station in Oaxaca is funded by CONACYT.